MSN

Entrez Summary: Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008].
UniProt Summary: Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation (PubMed:27405666). {ECO:0000269|PubMed:21549406, ECO:0000269|PubMed:27405666}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.14
I-BRD9 4μM R07 exp365	1.88

T cell aggregation
lymphocyte aggregation
membrane to membrane docking
positive regulation of early endosome to late endosome transport
regulation of protein localization to early endosome
cellular response to testosterone stimulus
positive regulation of protein localization to early endosome
invadopodium
leukocyte aggregation
positive regulation of protein localization to endosome
uropod
positive regulation of podosome assembly
regulation of protein localization to endosome
positive regulation of cytoplasmic transport
immunological synapse formation
regulation of podosome assembly
establishment of epithelial cell apical/basal polarity
regulation of early endosome to late endosome transport
pseudopodium
polarized epithelial cell differentiation
establishment of apical/basal cell polarity
establishment of monopolar cell polarity
microvillus membrane
establishment or maintenance of monopolar cell polarity
regulation of cytoplasmic transport
T cell migration
establishment of epithelial cell polarity
establishment of endothelial barrier
response to testosterone
T cell proliferation
cell periphery
morphogenesis of a polarized epithelium
interleukin-12-mediated signaling pathway
establishment or maintenance of epithelial cell apical/basal polarity
cellular response to interleukin-12
establishment or maintenance of bipolar cell polarity
establishment or maintenance of apical/basal cell polarity
response to interleukin-12
leukocyte cell-cell adhesion
endothelial cell development