MTNR1B

Gene Information

Official Symbol: MTNR1B
Official Name: melatonin receptor 1B
Aliases and Previous Symbols: N/A
Entrez ID: 4544
UniProt: P49286
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008].
UniProt Summary: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Olaparib 4μM R08 exp512	-2.19
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.93
Citral 75μM R06 exp275	-1.85
Vitamin-D3 40μM R08 exp536	-1.81
KU-0063794 3.8μM R02 exp71	-1.8
Pimelic-diphenylamide-106 5μM R00 exp28	-1.78
FBS-Wisent 0.1 R07 exp426	-1.77
FK-506 5μM R07 exp358	1.71
Centrinone 0.5μM R07 exp343	2.19

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6531
Expression level (log2 read counts): -5.6

Expression Distribution

7TM GPCR Srx
7TM GPCR Srsx
7tm 1

melatonin receptor activity
positive regulation of circadian sleep/wake cycle, non-REM sleep
regulation of neuronal action potential
negative regulation of transmission of nerve impulse
positive regulation of circadian sleep/wake cycle, sleep
negative regulation of cGMP-mediated signaling
positive regulation of transmission of nerve impulse
regulation of circadian sleep/wake cycle, non-REM sleep
negative regulation of delayed rectifier potassium channel activity
negative regulation of cytosolic calcium ion concentration
negative regulation of voltage-gated potassium channel activity
regulation of cGMP-mediated signaling
positive regulation of circadian rhythm
regulation of circadian sleep/wake cycle, sleep
regulation of transmission of nerve impulse
regulation of delayed rectifier potassium channel activity
negative regulation of potassium ion transmembrane transporter activity
regulation of circadian sleep/wake cycle
negative regulation of potassium ion transmembrane transport
negative regulation of nervous system process
positive regulation of behavior
negative regulation of potassium ion transport
negative regulation of insulin secretion
negative regulation of cation channel activity
negative regulation of peptide hormone secretion
regulation of action potential
regulation of potassium ion transmembrane transporter activity
positive regulation of blood vessel diameter
negative regulation of hormone secretion
positive regulation of nervous system process
negative regulation of ion transmembrane transporter activity
regulation of behavior
negative regulation of transporter activity
regulation of potassium ion transmembrane transport
negative regulation of cation transmembrane transport
negative regulation of ion transmembrane transport
regulation of potassium ion transport
regulation of circadian rhythm
negative regulation of transmembrane transport
negative regulation of protein secretion