MYH10
Gene Information
- Official Symbol: MYH10
- Official Name: myosin heavy chain 10
- Aliases and Previous Symbols: N/A
- Entrez ID: 4628
- UniProt: P35580
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Myosin N |
| Myosin head |
| Myosin tail 1 |
GO Terms
| fourth ventricle development |
| myosin II filament |
| third ventricle development |
| myosin II complex |
| modification of postsynaptic actin cytoskeleton |
| modification of postsynaptic structure |
| substrate-dependent cell migration, cell extension |
| ventricular cardiac muscle cell development |
| lateral ventricle development |
| postsynaptic actin cytoskeleton organization |
| plasma membrane repair |
| actin-dependent ATPase activity |
| actomyosin |
| postsynaptic cytoskeleton organization |
| modification of synaptic structure |
| adult heart development |
| ventricular cardiac muscle cell differentiation |
| microfilament motor activity |
| RNA stem-loop binding |
| nuclear migration |
| cardiac myofibril assembly |
| mRNA 5-UTR binding |
| cerebellar Purkinje cell layer development |
| ventricular system development |
| nucleus localization |
| substrate-dependent cell migration |
| myosin complex |
| ADP binding |
| polysome |
| coronary vasculature development |
| cerebellar cortex development |
| aorta development |
| brush border |
| neuromuscular process controlling balance |
| cleavage furrow |
| cardiac muscle cell development |
| cardiac cell development |
| myofibril assembly |
| mitotic cytokinesis |
| stress fiber |
| neuromuscular junction |
| artery development |
| postsynapse organization |
| cardiac muscle cell differentiation |
| plasma membrane organization |
| cytoskeleton-dependent cytokinesis |
| cytokinesis |
| cerebellum development |
| cellular component assembly involved in morphogenesis |
| neuromuscular process |
| cardiac septum development |
| actin filament-based movement |
| metencephalon development |
| actomyosin structure organization |
| cardiocyte differentiation |
| neuron migration |
| spindle |
| growth cone |
| striated muscle cell development |
| cell cortex |
| retina development in camera-type eye |
| muscle cell development |
| dendritic spine |
| hindbrain development |
| regulation of cell shape |
| midbody |
| cardiac muscle tissue development |
| cardiac chamber development |
| lamellipodium |
| striated muscle cell differentiation |
| calmodulin binding |
| actin filament binding |
| ATPase activity |
| muscle cell differentiation |
| telencephalon development |
| axon guidance |
| neuron projection guidance |
| actin binding |
| synapse organization |
| positive regulation of protein secretion |
| striated muscle tissue development |
| positive regulation of peptide secretion |
| muscle tissue development |
| camera-type eye development |
| glutamatergic synapse |
| eye development |
| visual system development |
| establishment of organelle localization |
| sensory system development |
| axonogenesis |
| neuronal cell body |
| in utero embryonic development |
| forebrain development |
| positive regulation of secretion by cell |
| axon development |
| endomembrane system organization |
| positive regulation of protein transport |
| cell morphogenesis involved in neuron differentiation |
| positive regulation of secretion |
| plasma membrane bounded cell projection assembly |
| supramolecular fiber organization |
| cell projection assembly |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| muscle structure development |
| wound healing |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| blood vessel development |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell division |
| actin cytoskeleton organization |
| regulation of peptide secretion |
| vasculature development |
| cell part morphogenesis |
| cardiovascular system development |
| heart development |
| sensory organ development |
| chemotaxis |
| taxis |
| cell population proliferation |
| cell morphogenesis involved in differentiation |
| actin filament-based process |
| response to wounding |
| organelle localization |
| mitotic cell cycle process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| neuron projection development |
| mitotic cell cycle |
| regulation of protein transport |
| cell morphogenesis |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| organelle assembly |
| head development |
| exocytosis |
| regulation of secretion |
| neuron development |
| cellular component morphogenesis |
| membrane organization |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| cell adhesion |
| biological adhesion |
| cell migration |
| embryo development |
| central nervous system development |
| positive regulation of transport |
| cell cycle process |
| secretion by cell |
| neuron differentiation |
| regulation of protein localization |
| export from cell |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| cytoskeleton organization |
| secretion |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| locomotion |
| cell cycle |
| nervous system process |
| ATP binding |
| intracellular transport |
| generation of neurons |
| movement of cell or subcellular component |
| neurogenesis |
| cell development |
| tissue development |
| establishment of localization in cell |
| regulation of transport |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nicotinamide 2000μM R01 exp50 | -2.13 |
| RO-3307 4.7μM R02 exp80 | -1.87 |
| Artemisinin 50μM R08 exp450 | -1.86 |
| Rifampicin 1μM R00 exp31 | -1.82 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5403
- Expression level (log2 read counts): 7.6
Expression Distribution
MYH10 Expression in NALM6 Cells: 7.6
