MYO19

Entrez Summary: N/A
UniProt Summary: Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824). {ECO:0000250|UniProtKB:Q5SV80, ECO:0000269|PubMed:19932026, ECO:0000269|PubMed:25447992, ECO:0000305|PubMed:23568824}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Lapatinib 5μM R01 exp47	-1.94
ZLN024 50μM R08 exp538	1.86

mitochondrion migration along actin filament
plus-end directed microfilament motor activity
myosin light chain binding
actin filament-based transport
regulation of mitochondrial fission
establishment of mitochondrion localization
myosin complex
mitochondrion localization
regulation of cytokinesis
actin filament-based movement
mitochondrial outer membrane
regulation of cell division
cytoskeleton-dependent intracellular transport
regulation of mitochondrion organization
ATPase activity
actin binding
establishment of organelle localization
actin filament-based process
organelle localization
regulation of cell cycle process
regulation of anatomical structure morphogenesis
regulation of cell cycle
mitochondrion
regulation of organelle organization
ATP binding
intracellular transport
movement of cell or subcellular component
establishment of localization in cell