NABP1

Entrez Summary: N/A
UniProt Summary: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Adefovir 20μM R07 exp332	1.82
Chloramphenicol 2μM R00 exp12	2.04

SOSS complex
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
double-strand break repair via homologous recombination
recombinational repair
single-stranded DNA binding
nuclear chromosome, telomeric region
response to ionizing radiation
mitotic cell cycle checkpoint
double-strand break repair
cell cycle checkpoint
DNA recombination
negative regulation of mitotic cell cycle
response to radiation
transcription by RNA polymerase II
DNA repair
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mitotic cell cycle
DNA metabolic process
cellular response to DNA damage stimulus
cell cycle process
nucleobase-containing compound biosynthetic process
response to abiotic stimulus
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
organic cyclic compound biosynthetic process
cell cycle
RNA binding
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular response to stress
cellular macromolecule biosynthetic process