NAGA

Entrez Summary: NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008].
UniProt Summary: Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids. {ECO:0000269|PubMed:9741689}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

alpha-N-acetylgalactosaminidase activity
alpha-galactosidase activity
glycosylceramide catabolic process
glycoside catabolic process
glycosphingolipid catabolic process
glycolipid catabolic process
glycosylceramide metabolic process
ceramide catabolic process
glycoside metabolic process
sphingolipid catabolic process
membrane lipid catabolic process
glycosyl compound catabolic process
oligosaccharide metabolic process
glycosphingolipid metabolic process
ceramide metabolic process
glycolipid metabolic process
liposaccharide metabolic process
carbohydrate catabolic process
glycosyl compound metabolic process
sphingolipid metabolic process
carbohydrate derivative catabolic process
cellular lipid catabolic process
membrane lipid metabolic process
lysosome
lipid catabolic process
carbohydrate metabolic process
cellular amide metabolic process
protein homodimerization activity
cellular lipid metabolic process
carbohydrate derivative metabolic process
organonitrogen compound catabolic process
lipid metabolic process
organic substance catabolic process
cellular catabolic process