NAT8B

Entrez Summary: N/A
UniProt Summary: May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). {ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:24556617}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

peptidyl-lysine N6-acetylation
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
N-acetyltransferase activity
amyloid-beta metabolic process
gastrulation with mouth forming second
endoplasmic reticulum-Golgi intermediate compartment membrane
endoplasmic reticulum-Golgi intermediate compartment
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
gastrulation
protein acylation
peptidyl-lysine modification
peptide metabolic process
embryonic morphogenesis
cellular amide metabolic process
peptidyl-amino acid modification
negative regulation of apoptotic process
negative regulation of programmed cell death
endoplasmic reticulum membrane
embryo development
negative regulation of cell death
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
positive regulation of gene expression