NCOA2

Entrez Summary: N/A
UniProt Summary: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK- ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:9430642}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
I-BRD9 4μM R07 exp365	-2.14
Thalidomide 20μM R07 exp406	-1.79

cellular response to Thyroglobulin triiodothyronine
response to Thyroglobulin triiodothyronine
thyroid hormone receptor coactivator activity
aryl hydrocarbon receptor binding
locomotor rhythm
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
nuclear receptor binding
circadian behavior
rhythmic behavior
nuclear hormone receptor binding
bile acid and bile salt transport
response to progesterone
circadian regulation of gene expression
nuclear receptor transcription coactivator activity
regulation of glucose metabolic process
monocarboxylic acid transport
organic hydroxy compound transport
regulation of cellular carbohydrate metabolic process
circadian rhythm
protein dimerization activity
response to ketone
locomotory behavior
regulation of carbohydrate metabolic process
protein domain specific binding
rhythmic process
nuclear body
transcription coactivator activity
carboxylic acid transport
organic acid transport
lipid transport
lipid localization
response to steroid hormone
chromatin binding
regulation of lipid metabolic process
regulation of small molecule metabolic process
organic anion transport
RNA polymerase II proximal promoter sequence-specific DNA binding
behavior
anion transport
protein-containing complex