NR2F1

Gene Information

Official Symbol: NR2F1
Official Name: nuclear receptor subfamily 2 group F member 1
Aliases and Previous Symbols: N/A
Entrez ID: 7025
UniProt: P10589
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014].
UniProt Summary: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:11682620}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8108
Expression level (log2 read counts): -0.9

Expression Distribution

Screen	Score
Fas-L 44ng/ml R08 exp482	-2.06
Rucaparib 6.5μM R08 exp520	-1.7
UM0125461 0.74μM R02 exp84	-1.7

Hormone recep
zf-C4

retinoic acid-responsive element binding
nuclear receptor activity
steroid hormone receptor activity
steroid hormone mediated signaling pathway
negative regulation of neuron projection development
intracellular receptor signaling pathway
hormone-mediated signaling pathway
transcription initiation from RNA polymerase II promoter
negative regulation of cell projection organization
cellular response to steroid hormone stimulus
DNA-templated transcription, initiation
negative regulation of neuron differentiation
DNA-binding transcription repressor activity, RNA polymerase II-specific
transcription coactivator activity
negative regulation of neurogenesis
negative regulation of nervous system development
RNA polymerase II regulatory region sequence-specific DNA binding
response to steroid hormone
negative regulation of cell development
sequence-specific DNA binding
transcription by RNA polymerase II
regulation of neuron projection development
RNA polymerase II proximal promoter sequence-specific DNA binding
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of neuron differentiation
DNA-binding transcription factor activity
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
regulation of neurogenesis
zinc ion binding
response to lipid
negative regulation of transcription by RNA polymerase II
response to hormone