NRL

Entrez Summary: This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008].
UniProt Summary: Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001). {ECO:0000269|PubMed:17335001, ECO:0000269|PubMed:21981118}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Maf N
bZIP Maf

positive regulation of rhodopsin gene expression
regulation of rhodopsin gene expression
retinal rod cell development
leucine zipper domain binding
eye photoreceptor cell development
eye photoreceptor cell differentiation
photoreceptor cell development
promoter-specific chromatin binding
photoreceptor cell differentiation
eye morphogenesis
visual perception
sensory perception of light stimulus
sensory organ morphogenesis
transcription coactivator activity
eye development
visual system development
sensory system development
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
sensory organ development
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
neuron development
animal organ morphogenesis
sensory perception
neuron differentiation
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
nervous system process
DNA binding
generation of neurons
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific