NUDT3

Gene Information

Official Symbol: NUDT3
Official Name: nudix hydrolase 3
Aliases and Previous Symbols: N/A
Entrez ID: 11165
UniProt: O95989
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate. {ECO:0000269|PubMed:9822604}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Arsenate 40μM R06 exp264	-1.98
Tenofovir 10μM R07 exp405	-1.79
SGC2043 10μM R03 exp152	-1.78
NMS-873 0.07μM R07 exp380	-1.77
UNC2400 2μM R03 exp156	1.7

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11978
Expression level (log2 read counts): 6.99

Expression Distribution

diphosphoinositol polyphosphate catabolic process
bis(5-adenosyl)-hexaphosphatase activity
adenosine 5-(hexahydrogen pentaphosphate) catabolic process
endopolyphosphatase activity
diadenosine hexaphosphate metabolic process
diadenosine polyphosphate catabolic process
bis(5-adenosyl)-pentaphosphatase activity
diphosphoinositol polyphosphate metabolic process
diadenosine pentaphosphate catabolic process
adenosine 5-(hexahydrogen pentaphosphate) metabolic process
diadenosine hexaphosphate catabolic process
diadenosine pentaphosphate metabolic process
diphosphoinositol-polyphosphate diphosphatase activity
inositol diphosphate pentakisphosphate diphosphatase activity
inositol diphosphate tetrakisphosphate diphosphatase activity
diadenosine polyphosphate metabolic process
m7G(5)pppN diphosphatase activity
inositol phosphate catabolic process
polyol catabolic process
purine ribonucleotide catabolic process
ribonucleotide catabolic process
purine nucleotide catabolic process
purine-containing compound catabolic process
alcohol catabolic process
inositol phosphate metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
organic hydroxy compound catabolic process
nucleobase-containing small molecule biosynthetic process
polyol metabolic process
organophosphate catabolic process
carbohydrate derivative catabolic process
magnesium ion binding
purine ribonucleotide metabolic process
alcohol metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleobase-containing compound catabolic process