ORMDL3

Entrez Summary: N/A
UniProt Summary: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling. {ECO:0000269|PubMed:20182505}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular sphingolipid homeostasis
SPOTS complex
negative regulation of ceramide biosynthetic process
negative regulation of sphingolipid biosynthetic process
regulation of sphingolipid biosynthetic process
regulation of membrane lipid metabolic process
regulation of ceramide biosynthetic process
negative regulation of lipid biosynthetic process
negative regulation of lipid metabolic process
ceramide metabolic process
specific granule membrane
secretory granule membrane
lipid homeostasis
negative regulation of cellular amide metabolic process
sphingolipid metabolic process
regulation of lipid biosynthetic process
membrane lipid metabolic process
regulation of lipid metabolic process
regulation of cellular amide metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
cellular chemical homeostasis
leukocyte mediated immunity
cellular amide metabolic process
exocytosis
cellular homeostasis
leukocyte activation
cellular lipid metabolic process
regulation of cellular component biogenesis
secretion by cell