OXSM

Entrez Summary: N/A
UniProt Summary: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. {ECO:0000269|PubMed:15668256}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ketoacyl-synt
Ketoacyl-synt C

3-oxoacyl-[acyl-carrier-protein] synthase activity
short-chain fatty acid biosynthetic process
medium-chain fatty acid biosynthetic process
medium-chain fatty acid metabolic process
short-chain fatty acid metabolic process
acyl-CoA metabolic process
thioester metabolic process
fatty acid biosynthetic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
monocarboxylic acid biosynthetic process
coenzyme metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
purine ribonucleotide metabolic process
fatty acid metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
monocarboxylic acid metabolic process
nucleobase-containing small molecule metabolic process
lipid biosynthetic process
small molecule biosynthetic process
cellular amide metabolic process
organophosphate metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
mitochondrion
small molecule metabolic process