P2RX1

Entrez Summary: The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013].
UniProt Summary: Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
YM155 0.0002μM R01 exp61	-1.94
Caffeine 2600μM R08 exp463	-1.86

serotonin production involved in inflammatory response
serotonin secretion by platelet
serotonin secretion
serotonin secretion involved in inflammatory response
serotonin transport
purinergic nucleotide receptor activity
ATP-gated ion channel activity
extracellularly ATP-gated cation channel activity
regulation of vascular smooth muscle contraction
insemination
integral component of presynaptic active zone membrane
copulation
integral component of nuclear inner membrane
production of molecular mediator involved in inflammatory response
cation channel activity
regulation of presynaptic cytosolic calcium ion concentration
purinergic nucleotide receptor signaling pathway
monoamine transport
purinergic receptor signaling pathway
neuronal action potential
synaptic transmission, glutamatergic
response to ATP
mating
neuron cellular homeostasis
integral component of postsynaptic membrane
ceramide biosynthetic process
ammonium transport
transmission of nerve impulse
regulation of vasoconstriction
regulation of smooth muscle contraction
excitatory postsynaptic potential
chemical synaptic transmission, postsynaptic
exocytic process
regulation of synaptic vesicle exocytosis
ceramide metabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
sphingolipid biosynthetic process
specific granule membrane
action potential
secretory granule membrane