P2RX4
Gene Information
- Official Symbol: P2RX4
- Official Name: purinergic receptor P2X 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 5025
- UniProt: Q99571
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| P2X receptor |
GO Terms
| microglial cell migration |
| ligand-gated calcium channel activity |
| sensory perception of touch |
| positive regulation of microglial cell migration |
| extracellularly ATP-gated cation channel activity |
| regulation of microglial cell migration |
| purinergic nucleotide receptor activity |
| ATP-gated ion channel activity |
| positive regulation of glial cell migration |
| endothelial cell activation |
| positive regulation of prostaglandin secretion |
| regulation of prostaglandin secretion |
| relaxation of cardiac muscle |
| behavioral response to pain |
| positive regulation of endothelial cell chemotaxis |
| regulation of glial cell migration |
| positive regulation of icosanoid secretion |
| integral component of nuclear inner membrane |
| cellular response to ATP |
| positive regulation of fatty acid transport |
| macrophage migration |
| regulation of icosanoid secretion |
| positive regulation of macrophage migration |
| purinergic nucleotide receptor signaling pathway |
| relaxation of muscle |
| regulation of endothelial cell chemotaxis |
| cellular response to zinc ion |
| negative regulation of cardiac muscle hypertrophy |
| regulation of fatty acid transport |
| negative regulation of muscle hypertrophy |
| purinergic receptor signaling pathway |
| neuronal action potential |
| regulation of ruffle assembly |
| response to pain |
| response to ATP |
| positive regulation of organic acid transport |
| response to fluid shear stress |
| glial cell migration |
| regulation of macrophage migration |
| positive regulation of nitric oxide biosynthetic process |
| positive regulation of nitric oxide metabolic process |
| positive regulation of calcium-mediated signaling |
| response to axon injury |
| response to ischemia |
| terminal bouton |
| positive regulation of anion transport |
| positive regulation of reactive oxygen species biosynthetic process |
| membrane depolarization |
| response to zinc ion |
| positive regulation of calcium ion transport into cytosol |
| positive regulation of blood vessel endothelial cell migration |
| transmission of nerve impulse |
| copper ion binding |
| regulation of cardiac muscle hypertrophy |
| regulation of nitric oxide biosynthetic process |
| regulation of organic acid transport |
| regulation of muscle hypertrophy |
| positive regulation of lipid transport |
| excitatory postsynaptic potential |
| cellular response to nutrient |
| chemical synaptic transmission, postsynaptic |
| multicellular organismal response to stress |
| positive regulation of gliogenesis |
| cell body |
| sensory perception of pain |
| regulation of cardiac muscle contraction |
| positive regulation of lipid localization |
| regulation of muscle adaptation |
| regulation of reactive oxygen species biosynthetic process |
| regulation of sodium ion transport |
| regulation of blood vessel endothelial cell migration |
| regulation of striated muscle contraction |
| action potential |
| regulation of anion transport |
| positive regulation of reactive oxygen species metabolic process |
| regulation of calcium-mediated signaling |
| positive regulation of endothelial cell migration |
| regulation of calcium ion transport into cytosol |
| regulation of postsynaptic membrane potential |
| regulation of lipid transport |
| regulation of gliogenesis |
| positive regulation of calcium ion transport |
| myeloid leukocyte migration |
| positive regulation of leukocyte migration |
| multicellular organismal signaling |
| response to organophosphorus |
| positive regulation of chemotaxis |
| regulation of lipid localization |
| positive regulation of epithelial cell migration |
| calcium-mediated signaling |
| dendritic spine |
| response to purine-containing compound |
| regulation of endothelial cell migration |
| regulation of muscle contraction |
| positive regulation of protein kinase B signaling |
| sensory perception of mechanical stimulus |
| regulation of reactive oxygen species metabolic process |
| regulation of blood pressure |
| tissue homeostasis |
| cellular response to metal ion |
| regulation of leukocyte migration |
| calcium ion transmembrane transport |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| regulation of chemotaxis |
| gliogenesis |
| response to nutrient |
| regulation of protein kinase B signaling |
| regulation of epithelial cell migration |
| cellular response to inorganic substance |
| cellular response to nutrient levels |
| regulation of muscle system process |
| regulation of heart contraction |
| regulation of calcium ion transport |
| calcium ion transport |
| postsynaptic density |
| cellular response to extracellular stimulus |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| apoptotic signaling pathway |
| regulation of blood circulation |
| blood coagulation |
| coagulation |
| divalent metal ion transport |
| hemostasis |
| muscle system process |
| lysosomal membrane |
| divalent inorganic cation transport |
| cadherin binding |
| multicellular organismal homeostasis |
| regulation of cytosolic calcium ion concentration |
| cellular response to external stimulus |
| signaling receptor binding |
| second-messenger-mediated signaling |
| protein homooligomerization |
| anatomical structure homeostasis |
| regulation of neurotransmitter levels |
| response to metal ion |
| neuronal cell body |
| leukocyte migration |
| regulation of metal ion transport |
| blood circulation |
| circulatory system process |
| cellular response to drug |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of membrane potential |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| calcium ion homeostasis |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| positive regulation of neurogenesis |
| wound healing |
| divalent inorganic cation homeostasis |
| regulation of body fluid levels |
| response to nutrient levels |
| positive regulation of cell migration |
| protein complex oligomerization |
| positive regulation of cell motility |
| response to extracellular stimulus |
| response to inorganic substance |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| positive regulation of cell development |
| cell junction |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| behavior |
| response to wounding |
| regulation of system process |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| cellular response to nitrogen compound |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| cation homeostasis |
| regulation of cell projection organization |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| regulation of secretion |
| regulation of neurogenesis |
| cation transport |
| zinc ion binding |
| regulation of cell migration |
| protein homodimerization activity |
| cellular homeostasis |
| regulation of cell motility |
| regulation of cellular localization |
| response to organic cyclic compound |
| apoptotic process |
| regulation of nervous system development |
| regulation of cell development |
| ion transmembrane transport |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| sensory perception |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| response to organonitrogen compound |
| response to drug |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| cellular response to oxygen-containing compound |
| cell activation |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| cell death |
| regulation of response to external stimulus |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| transmembrane transport |
| locomotion |
| positive regulation of developmental process |
| ion transport |
| nervous system process |
| integral component of plasma membrane |
| response to endogenous stimulus |
| ATP binding |
| generation of neurons |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| neurogenesis |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
| regulation of transport |
| system process |
| positive regulation of cellular biosynthetic process |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rapamycin 2μM plus FK-506 5μM R07 exp308 | 1.76 |
| UMK57 1μM R01 exp59 | 1.77 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4164
- Expression level (log2 read counts): 4.92
Expression Distribution
P2RX4 Expression in NALM6 Cells: 4.92
