P2RY8

Gene Information

Official Symbol: P2RY8
Official Name: P2Y receptor family member 8
Aliases and Previous Symbols: N/A
Entrez ID: 286530
UniProt: Q86VZ1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008].
UniProt Summary: Probable receptor for purines coupled to G-proteins.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3267
Expression level (log2 read counts): 6.77

Expression Distribution

Screen	Score
Epothilone-B 0.0015μM R05 exp231	-1.92
Docetaxel 0.002μM R01 exp45	-1.75
VER-155008 3.9μM R06 exp301	1.99

G protein-coupled purinergic nucleotide receptor activity
G protein-coupled purinergic nucleotide receptor signaling pathway
G protein-coupled purinergic receptor signaling pathway
purinergic nucleotide receptor signaling pathway
purinergic receptor signaling pathway
positive regulation of Rho protein signal transduction
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
positive regulation of Ras protein signal transduction
positive regulation of small GTPase mediated signal transduction
phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of Rho protein signal transduction
regulation of Ras protein signal transduction
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
regulation of small GTPase mediated signal transduction
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
G protein-coupled receptor activity
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
positive regulation of intracellular signal transduction
chemical homeostasis
G protein-coupled receptor signaling pathway
integral component of plasma membrane
homeostatic process
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction