PDE6G

Entrez Summary: This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009].
UniProt Summary: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

rhodopsin mediated signaling pathway
cGMP binding
3,5-cyclic-GMP phosphodiesterase activity
photoreceptor outer segment membrane
phototransduction, visible light
photoreceptor disc membrane
regulation of rhodopsin mediated signaling pathway
positive regulation of G protein-coupled receptor signaling pathway
spectrin binding
enzyme inhibitor activity
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of ERBB signaling pathway
Wnt signaling pathway, calcium modulating pathway
phototransduction
detection of visible light
detection of light stimulus
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
cellular response to light stimulus
detection of external stimulus
detection of abiotic stimulus
non-canonical Wnt signaling pathway
regulation of G protein-coupled receptor signaling pathway
activation of MAPK activity
cellular response to radiation
visual perception
sensory perception of light stimulus
positive regulation of MAP kinase activity
response to light stimulus
cellular response to abiotic stimulus
cellular response to environmental stimulus
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
Wnt signaling pathway
cell-cell signaling by wnt
cell surface receptor signaling pathway involved in cell-cell signaling
response to radiation
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity