PDE7B

Entrez Summary: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009].
UniProt Summary: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cAMP catabolic process
3,5-cyclic-AMP phosphodiesterase activity
cyclic nucleotide catabolic process
cAMP metabolic process
purine ribonucleotide catabolic process
ribonucleotide catabolic process
cyclic nucleotide metabolic process
purine nucleotide catabolic process
purine-containing compound catabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
carbohydrate derivative catabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleobase-containing compound catabolic process
chemical synaptic transmission
anterograde trans-synaptic signaling
heterocycle catabolic process
cellular nitrogen compound catabolic process
trans-synaptic signaling
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
synaptic signaling
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
organophosphate metabolic process
carbohydrate derivative metabolic process
organonitrogen compound catabolic process
nucleobase-containing compound biosynthetic process
cell-cell signaling
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process