PDE8B

Entrez Summary: The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010].
UniProt Summary: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Brefeldin A 0.02μM R00 exp8	-2.42
Rifampicin 10μM R00 exp32	2.07

cAMP catabolic process
3,5-cyclic-AMP phosphodiesterase activity
cyclic nucleotide catabolic process
cAMP metabolic process
purine ribonucleotide catabolic process
ribonucleotide catabolic process
cyclic nucleotide metabolic process
purine nucleotide catabolic process
purine-containing compound catabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
carbohydrate derivative catabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
nucleotide metabolic process
cellular component
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
organophosphate metabolic process
carbohydrate derivative metabolic process
organonitrogen compound catabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
G protein-coupled receptor signaling pathway
cellular nitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process