PFKFB4

Gene Information

Official Symbol: PFKFB4
Official Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Aliases and Previous Symbols: N/A
Entrez ID: 5210
UniProt: Q16877
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Synthesis and degradation of fructose 2,6-bisphosphate.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8721
Expression level (log2 read counts): 2.12

Expression Distribution

His Phos 1
6PF2K

6-phosphofructo-2-kinase activity
fructose-2,6-bisphosphate 2-phosphatase activity
fructose 2,6-bisphosphate metabolic process
fructose metabolic process
positive regulation of glycolytic process
carbohydrate phosphorylation
positive regulation of nucleotide metabolic process
positive regulation of purine nucleotide metabolic process
positive regulation of ATP metabolic process
positive regulation of carbohydrate metabolic process
regulation of glycolytic process
regulation of carbohydrate catabolic process
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of ATP metabolic process
positive regulation of small molecule metabolic process
hexose metabolic process
regulation of generation of precursor metabolites and energy
cellular carbohydrate metabolic process
monosaccharide metabolic process
regulation of carbohydrate metabolic process
dephosphorylation
positive regulation of cellular catabolic process
regulation of small molecule metabolic process
positive regulation of catabolic process
carbohydrate metabolic process
regulation of cellular catabolic process
organophosphate metabolic process
regulation of catabolic process
carbohydrate derivative metabolic process
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
phosphorylation
ATP binding
regulation of phosphorylation
small molecule metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of nucleobase-containing compound metabolic process