PHYKPL

Gene Information
  • Official Symbol: PHYKPL
  • Official Name: 5-phosphohydroxy-L-lysine phospho-lyase
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 85007
  • UniProt: Q8IUZ5
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. Mutations in this gene may cause phosphohydroxylysinuria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
  • UniProt Summary: Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde. {ECO:0000269|PubMed:22241472}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 9241
  • Expression level (log2 read counts): 5.55

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1