PID1
Gene Information
- Official Symbol: PID1
- Official Name: phosphotyrosine interaction domain containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 55022
- UniProt: Q7Z2X4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Increases proliferation of preadipocytes without affecting adipocytic differentiation. {ECO:0000269|PubMed:16815647}.
Pfam Domains GO Terms
Pfam Domains
| PID |
GO Terms
| negative regulation of ATP biosynthetic process |
| positive regulation of fat cell proliferation |
| negative regulation of purine nucleotide biosynthetic process |
| negative regulation of nucleotide biosynthetic process |
| regulation of mitochondrial fusion |
| regulation of fat cell proliferation |
| positive regulation of ATP biosynthetic process |
| negative regulation of glucose import |
| negative regulation of glucose transmembrane transport |
| cellular response to leptin stimulus |
| negative regulation of purine nucleotide metabolic process |
| regulation of ATP biosynthetic process |
| negative regulation of nucleotide metabolic process |
| mitochondrion morphogenesis |
| positive regulation of nucleotide biosynthetic process |
| negative regulation of protein localization to plasma membrane |
| positive regulation of purine nucleotide biosynthetic process |
| response to leptin |
| negative regulation of protein localization to cell periphery |
| negative regulation of ATP metabolic process |
| negative regulation of protein localization to membrane |
| cellular response to interleukin-6 |
| negative regulation of insulin receptor signaling pathway |
| negative regulation of cellular response to insulin stimulus |
| response to interleukin-6 |
| regulation of purine nucleotide biosynthetic process |
| regulation of nucleotide biosynthetic process |
| positive regulation of ATP metabolic process |
| positive regulation of purine nucleotide metabolic process |
| positive regulation of nucleotide metabolic process |
| cellular response to fatty acid |
| regulation of glucose import |
| energy reserve metabolic process |
| regulation of insulin receptor signaling pathway |
| regulation of mitochondrial membrane potential |
| regulation of cellular response to insulin stimulus |
| regulation of glucose transmembrane transport |
| response to fatty acid |
| negative regulation of small molecule metabolic process |
| regulation of protein localization to plasma membrane |
| positive regulation of reactive oxygen species metabolic process |
| fat cell differentiation |
| negative regulation of cellular protein localization |
| regulation of protein localization to cell periphery |
| negative regulation of transmembrane transport |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| positive regulation of small molecule metabolic process |
| regulation of reactive oxygen species metabolic process |
| regulation of mitochondrion organization |
| regulation of protein localization to membrane |
| cellular response to acid chemical |
| energy derivation by oxidation of organic compounds |
| cellular response to tumor necrosis factor |
| response to tumor necrosis factor |
| response to acid chemical |
| negative regulation of protein phosphorylation |
| generation of precursor metabolites and energy |
| regulation of small molecule metabolic process |
| regulation of membrane potential |
| mitochondrion organization |
| negative regulation of phosphorylation |
| negative regulation of transport |
| cell part morphogenesis |
| cellular response to lipid |
| regulation of cellular protein localization |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| negative regulation of protein modification process |
| cellular response to hormone stimulus |
| cellular component morphogenesis |
| response to lipid |
| response to hormone |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| oxidation-reduction process |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| response to cytokine |
| negative regulation of protein metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of RNA metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Taxol 0.002μM R01 exp54 | -1.78 |
| UMK57 1μM R01 exp59 | -1.76 |
| Hypoxia 5%O2 R04 exp191 | -1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18097
- Expression level (log2 read counts): -1.14
Expression Distribution
PID1 Expression in NALM6 Cells: -1.14
