PIGK

Entrez Summary: N/A
UniProt Summary: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Senexin-A 25μM R07 exp400	-1.95
OICR-9429 10μM R03 exp142	1.81

GPI-anchor transamidase complex
GPI-anchor transamidase activity
attachment of GPI anchor to protein
GPI anchor binding
protein disulfide isomerase activity
protein localization to cell surface
cysteine-type peptidase activity
GPI anchor biosynthetic process
GPI anchor metabolic process
glycolipid biosynthetic process
protein lipidation
lipoprotein biosynthetic process
integral component of endoplasmic reticulum membrane
glycolipid metabolic process
phosphatidylinositol biosynthetic process
liposaccharide metabolic process
lipoprotein metabolic process
membrane lipid biosynthetic process
phosphatidylinositol metabolic process
membrane lipid metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
carbohydrate derivative biosynthetic process
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
proteolysis
organonitrogen compound biosynthetic process
cellular protein localization
cellular macromolecule localization
cellular macromolecule biosynthetic process
macromolecule biosynthetic process