PIP4K2B

Entrez Summary: N/A
UniProt Summary: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:9038203}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
PRIM1	0.472
POLR2J3	0.441

1-phosphatidylinositol-5-phosphate 4-kinase activity
1-phosphatidylinositol-4-phosphate 5-kinase activity
positive regulation of autophagosome assembly
positive regulation of vacuole organization
regulation of autophagosome assembly
regulation of vacuole organization
phosphatidylinositol phosphorylation
lipid phosphorylation
positive regulation of macroautophagy
autophagosome
positive regulation of organelle assembly
phosphatidylinositol biosynthetic process
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of autophagy
phosphatidylinositol metabolic process
regulation of macroautophagy
lipid modification
glycerophospholipid biosynthetic process
regulation of organelle assembly
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
regulation of autophagy
positive regulation of cellular catabolic process
phospholipid metabolic process
glycerolipid metabolic process
positive regulation of catabolic process
positive regulation of cellular component biogenesis
organophosphate biosynthetic process
lipid biosynthetic process
positive regulation of organelle organization
regulation of cellular catabolic process
protein homodimerization activity
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
regulation of cellular component biogenesis
regulation of catabolic process
positive regulation of cellular component organization
lipid metabolic process