PIP5KL1

Entrez Summary: N/A
UniProt Summary: May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

1-phosphatidylinositol-4-phosphate 5-kinase activity
negative regulation of mitochondrial membrane potential
negative regulation of membrane potential
phosphatidylinositol phosphorylation
lipid phosphorylation
regulation of mitochondrial membrane potential
cell projection
phosphatidylinositol metabolic process
lipid modification
negative regulation of cell migration
negative regulation of cell motility
glycerophospholipid metabolic process
negative regulation of cellular component movement
negative regulation of locomotion
phospholipid metabolic process
glycerolipid metabolic process
negative regulation of protein phosphorylation
regulation of membrane potential
negative regulation of phosphorylation
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of cell migration
organophosphate metabolic process
regulation of cell motility
cellular lipid metabolic process
regulation of locomotion
regulation of cellular component movement
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
lipid metabolic process
phosphorylation
regulation of protein phosphorylation
ATP binding
regulation of apoptotic process
regulation of programmed cell death
regulation of phosphorylation