PITPNM1

Entrez Summary: N/A
UniProt Summary: Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. {ECO:0000250, ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylcholine transporter activity
phosphatidylinositol transfer activity
phosphatidic acid binding
phosphatidylcholine binding
phototransduction
cleavage furrow
receptor tyrosine kinase binding
detection of light stimulus
cytoplasmic ribonucleoprotein granule
cell body
lipid droplet
phosphatidylinositol binding
phospholipid transport
Golgi cisterna membrane
phosphatidylinositol biosynthetic process
detection of external stimulus
organophosphate ester transport
detection of abiotic stimulus
microtubule organizing center
midbody
phosphatidylinositol metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
lipid transport
response to light stimulus
glycerophospholipid metabolic process
lipid localization
phospholipid metabolic process
glycerolipid metabolic process
response to radiation
organic anion transport
organophosphate biosynthetic process
lipid biosynthetic process
anion transport
detection of stimulus
calcium ion binding
brain development
head development
organophosphate metabolic process