PKP1

Entrez Summary: This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
UniProt Summary: Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis. {ECO:0000269|PubMed:9326952}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intermediate filament bundle assembly
intermediate filament binding
messenger ribonucleoprotein complex
structural constituent of epidermis
lamin binding
intermediate filament organization
desmosome
intermediate filament cytoskeleton organization
intermediate filament-based process
negative regulation of mRNA catabolic process
negative regulation of RNA catabolic process
ficolin-1-rich granule membrane
cornified envelope
negative regulation of mRNA metabolic process
cell-cell adherens junction
cell-cell junction assembly
cornification
intermediate filament
cell-cell junction organization
cell junction assembly
cell-cell junction
regulation of mRNA catabolic process
cell junction organization
keratinization
negative regulation of cellular catabolic process
keratinocyte differentiation
negative regulation of catabolic process
cadherin binding
epidermal cell differentiation
regulation of mRNA metabolic process
skin development
epidermis development
supramolecular fiber organization
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
cell-cell adhesion
granulocyte activation
leukocyte degranulation