PLEKHA8

Entrez Summary: N/A
UniProt Summary: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. {ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:16103222, ECO:0000269|PubMed:17687330}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GLTP
PH

glycolipid transfer activity
glycolipid binding
ceramide binding
ER to Golgi ceramide transport
glycolipid transport
ceramide 1-phosphate binding
intermembrane lipid transfer
ceramide 1-phosphate transfer activity
ceramide 1-phosphate transport
ceramide transport
phosphatidylinositol-4-phosphate binding
intracellular lipid transport
carbohydrate derivative transport
phospholipid transport
phosphatidylinositol biosynthetic process
organophosphate ester transport
lipid binding
phosphatidylinositol metabolic process
trans-Golgi network
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
lipid transport
glycerophospholipid metabolic process
lipid localization
phospholipid metabolic process
glycerolipid metabolic process
organic anion transport
organophosphate biosynthetic process
lipid biosynthetic process
anion transport
Golgi membrane
membrane organization
organophosphate metabolic process
cellular lipid metabolic process
Golgi apparatus
lipid metabolic process
ion transport
protein transport
intracellular transport