PLSCR4

Entrez Summary: N/A
UniProt Summary: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CD4 receptor binding
phospholipid scramblase activity
plasma membrane phospholipid scrambling
phospholipid translocation
lipid translocation
regulation of membrane lipid distribution
phospholipid transport
plasma membrane organization
organophosphate ester transport
SH3 domain binding
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cellular response to biotic stimulus
lipid transport
response to lipopolysaccharide
lipid localization
response to molecule of bacterial origin
enzyme binding
endomembrane system organization
organic anion transport
cellular response to lipid
anion transport
response to bacterium
calcium ion binding
membrane organization
response to lipid
cellular response to oxygen-containing compound
response to other organism
response to external biotic stimulus
response to biotic stimulus
ion transport
response to oxygen-containing compound