PMP2

Gene Information
  • Official Symbol: PMP2
  • Official Name: peripheral myelin protein 2
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 5375
  • UniProt: P02689
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: The protein encoded by this gene localizes to myelin sheaths of the peripheral nervous system. The encoded protein can bind both the membrane layers of the sheaths and monomeric lipids, and is thought to provide stability to the sheath. A defect in this gene was shown to be a cause of dominant demyelinating CMT neuropathy. [provided by RefSeq, Jan 2017].
  • UniProt Summary: May play a role in lipid transport protein in Schwann cells. May bind cholesterol. {ECO:0000269|PubMed:20421974}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 18803
  • Expression level (log2 read counts): 2.3

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1