POU5F1
Gene Information
- Official Symbol: POU5F1
- Official Name: POU class 5 homeobox 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5460
- UniProt: Q01860
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pou |
| Homeobox |
GO Terms
| regulation of asymmetric cell division |
| endodermal cell fate specification |
| endodermal cell fate commitment |
| negative regulation of gene silencing by miRNA |
| negative regulation of gene silencing by RNA |
| negative regulation of posttranscriptional gene silencing |
| mRNA transcription by RNA polymerase II |
| mRNA transcription |
| cell fate commitment involved in formation of primary germ layer |
| miRNA binding |
| negative regulation of gene silencing |
| endodermal cell differentiation |
| endoderm formation |
| somatic stem cell population maintenance |
| endoderm development |
| transcription regulatory region sequence-specific DNA binding |
| regulation of gene silencing by miRNA |
| cell fate specification |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| blastocyst development |
| formation of primary germ layer |
| regulation of gene silencing |
| stem cell population maintenance |
| maintenance of cell number |
| gastrulation |
| regulation of cell division |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| cell fate commitment |
| ubiquitin protein ligase binding |
| in utero embryonic development |
| sequence-specific DNA binding |
| transcription by RNA polymerase II |
| embryonic morphogenesis |
| response to wounding |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| DNA-binding transcription factor activity |
| mRNA metabolic process |
| negative regulation of transcription by RNA polymerase II |
| anatomical structure formation involved in morphogenesis |
| embryo development |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| mitochondrion |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UM0011500 5μM R05 exp245 | 1.78 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4833
- Expression level (log2 read counts): 3.4
Expression Distribution
POU5F1 Expression in NALM6 Cells: 3.4
