PPIP5K1

Entrez Summary: This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

5-diphosphoinositol pentakisphosphate 3-kinase activity
diphosphoinositol-pentakisphosphate kinase activity
inositol-1,3,4,5,6-pentakisphosphate kinase activity
inositol heptakisphosphate kinase activity
inositol hexakisphosphate 1-kinase activity
inositol hexakisphosphate 3-kinase activity
inositol hexakisphosphate kinase activity
inositol hexakisphosphate 5-kinase activity
inositol metabolic process
inositol phosphate biosynthetic process
inositol phosphate metabolic process
polyol biosynthetic process
polyol metabolic process
alcohol biosynthetic process
cellular carbohydrate metabolic process
organic hydroxy compound biosynthetic process
alcohol metabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
organophosphate biosynthetic process
small molecule biosynthetic process
organophosphate metabolic process
phosphorylation
ATP binding
small molecule metabolic process