PPM1K

Entrez Summary: This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of pyruvate dehydrogenase activity
regulation of pyruvate dehydrogenase activity
magnesium-dependent protein serine/threonine phosphatase activity
branched-chain amino acid catabolic process
branched-chain amino acid metabolic process
positive regulation of oxidoreductase activity
protein serine/threonine phosphatase activity
regulation of oxidoreductase activity
cellular amino acid catabolic process
protein dephosphorylation
carboxylic acid catabolic process
organic acid catabolic process
dephosphorylation
cellular amino acid metabolic process
mitochondrial matrix
small molecule catabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
mitochondrion
positive regulation of catalytic activity
small molecule metabolic process
organic substance catabolic process
positive regulation of molecular function
cellular catabolic process