PPP1R14D

Gene Information

Official Symbol: PPP1R14D
Official Name: protein phosphatase 1 regulatory inhibitor subunit 14D
Aliases and Previous Symbols: N/A
Entrez ID: 54866
UniProt: Q9NXH3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. {ECO:0000269|PubMed:12974676}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5976
Expression level (log2 read counts): -3.13

Expression Distribution

negative regulation of protein serine/threonine phosphatase activity
positive regulation of protein serine/threonine phosphatase activity
protein serine/threonine phosphatase inhibitor activity
positive regulation of phosphoprotein phosphatase activity
positive regulation of phosphatase activity
positive regulation of protein dephosphorylation
positive regulation of dephosphorylation
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
regulation of phosphatase activity
regulation of dephosphorylation
negative regulation of hydrolase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
positive regulation of hydrolase activity
negative regulation of catalytic activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
negative regulation of molecular function
positive regulation of protein modification process
regulation of hydrolase activity
positive regulation of catalytic activity
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process