PPP1R15A

Gene Information

Official Symbol: PPP1R15A
Official Name: protein phosphatase 1 regulatory subunit 15A
Aliases and Previous Symbols: N/A
Entrez ID: 23645
UniProt: O75807
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. {ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:8139541}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Campthothecin 0.001μM R06 exp270	-2.19
Bleomycin 5μM R08 exp459	-1.7
Metformin 40μM R03 exp132	1.74
R-DABN 8μM R03 exp111	1.79
Salubrinal 20μM R07 exp399	1.82
SGC2096 2.6μM R03 exp153	2.21
BI-2536 0.0042μM R03 exp95	2.37

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6974
Expression level (log2 read counts): 4.68

Expression Distribution

positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
regulation of translational initiation by eIF2 alpha dephosphorylation
positive regulation of peptidyl-serine dephosphorylation
positive regulation of translational initiation in response to stress
negative regulation of PERK-mediated unfolded protein response
regulation of peptidyl-serine dephosphorylation
positive regulation of translation in response to stress
regulation of translational initiation in response to stress
protein phosphatase type 1 complex
regulation of PERK-mediated unfolded protein response
negative regulation of endoplasmic reticulum unfolded protein response
protein phosphatase activator activity
regulation of translation in response to stress
protein phosphatase 1 binding
positive regulation of phosphoprotein phosphatase activity
regulation of endoplasmic reticulum unfolded protein response
positive regulation of translational initiation
protein phosphatase regulator activity
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
positive regulation of phosphatase activity
positive regulation of response to endoplasmic reticulum stress
positive regulation of protein dephosphorylation
negative regulation of response to endoplasmic reticulum stress
positive regulation of dephosphorylation
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
regulation of translational initiation
regulation of response to endoplasmic reticulum stress
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
positive regulation of translation
protein localization to endoplasmic reticulum
regulation of protein dephosphorylation
cell cycle arrest
intrinsic apoptotic signaling pathway
positive regulation of cellular amide metabolic process
mitochondrial outer membrane
regulation of phosphatase activity