PPP1R17

Gene Information
  • Official Symbol: PPP1R17
  • Official Name: protein phosphatase 1 regulatory subunit 17
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 10842
  • UniProt: O96001
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
  • UniProt Summary: Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes. {ECO:0000250}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 14955
  • Expression level (log2 read counts): -5.01

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1