PQLC2

Entrez Summary: N/A
UniProt Summary: Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. {ECO:0000269|PubMed:22822152, ECO:0000269|PubMed:23169667}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lysine transport
arginine transmembrane transporter activity
L-lysine transmembrane transporter activity
amino acid homeostasis
L-lysine transmembrane transport
L-lysine transport
arginine transmembrane transport
basic amino acid transmembrane transporter activity
arginine transport
basic amino acid transmembrane transport
integral component of organelle membrane
basic amino acid transport
L-alpha-amino acid transmembrane transport
anion homeostasis
L-amino acid transport
drug transmembrane transport
amino acid transmembrane transport
amino acid transport
carboxylic acid transmembrane transport
organic acid transmembrane transport
drug transport
anion transmembrane transport
organic acid transport
carboxylic acid transport
lysosomal membrane
organic anion transport
anion transport
cation transmembrane transport
intracellular membrane-bounded organelle
ion homeostasis
cation transport
ion transmembrane transport
response to drug
chemical homeostasis
transmembrane transport
ion transport
homeostatic process
nitrogen compound transport