PRCP

Entrez Summary: N/A
UniProt Summary: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
42°C R08 exp539	-2.08
L-BMAA 500 to 750μM on day4 R04 exp185	1.93

Peptidase S28
Abhydrolase 6

plasma kallikrein-kinin cascade
kinin cascade
regulation of thyroid hormone mediated signaling pathway
serine-type carboxypeptidase activity
basal part of cell
angiogenesis involved in wound healing
dipeptidyl-peptidase activity
blood coagulation, intrinsic pathway
negative regulation of systemic arterial blood pressure
blood coagulation, fibrin clot formation
protein activation cascade
energy homeostasis
negative regulation of blood pressure
azurophil granule membrane
ficolin-1-rich granule membrane
acute inflammatory response
regulation of blood vessel endothelial cell migration
regulation of systemic arterial blood pressure
regulation of endothelial cell migration
regulation of reactive oxygen species metabolic process
regulation of blood pressure
glucose homeostasis
carbohydrate homeostasis
regulation of epithelial cell migration
blood coagulation
coagulation
hemostasis
angiogenesis
multicellular organismal homeostasis
blood circulation
circulatory system process
blood vessel morphogenesis
wound healing
blood vessel development
neutrophil degranulation
neutrophil activation involved in immune response
regulation of body fluid levels
inflammatory response
neutrophil mediated immunity
neutrophil activation