PRG2

Entrez Summary: N/A
UniProt Summary: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. {ECO:0000269|PubMed:10913121}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TIC10 10μM R08 exp532	-1.73
All-trans-Retinoic-Acid 8μM R07 exp333	1.79
RO-3306 3 to 4μM on day4 R04 exp165	1.79
Dimethyloxaloylglycine 11μM R07 exp314	1.84
D-Fructose 10000μM R06 exp279	2.07
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.13

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

extracellular matrix structural constituent conferring compression resistance
transport vesicle
ficolin-1-rich granule lumen
heparin binding
carbohydrate binding
defense response to bacterium
collagen-containing extracellular matrix
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
response to bacterium
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
defense response to other organism
secretion by cell
export from cell
cell activation
immune effector process
secretion
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
immune response
extracellular region
vesicle-mediated transport