PTCH1

Entrez Summary: This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Sterol-sensing
Patched

neural plate axis specification
response to chlorate
smoothened binding
hedgehog receptor activity
hedgehog family protein binding
epidermal cell fate specification
neural plate pattern specification
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
cell proliferation involved in metanephros development
patched binding
dendritic growth cone
keratinocyte proliferation
neural plate development
cell proliferation involved in kidney development
negative regulation of multicellular organism growth
commissural neuron axon guidance
positive regulation of cholesterol efflux
negative regulation of cell division
cellular response to cholesterol
dorsal/ventral neural tube patterning
mammary gland epithelial cell differentiation
cellular response to sterol
positive regulation of sterol transport
positive regulation of cholesterol transport
regulation of cholesterol efflux
positive regulation of epidermal cell differentiation
response to cholesterol
pharyngeal system development
axonal growth cone
cyclin binding
response to sterol
negative regulation of smoothened signaling pathway
liver regeneration
mammary gland duct morphogenesis
neural tube patterning
spinal cord motor neuron differentiation
hindlimb morphogenesis
embryonic axis specification
cell fate determination
positive regulation of epidermis development