PTGES2

Entrez Summary: The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009].
UniProt Summary: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2). {ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:18198127}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

prostaglandin-E synthase activity
glutathione binding
cyclooxygenase pathway
lyase activity
prostanoid biosynthetic process
prostaglandin biosynthetic process
protein disulfide oxidoreductase activity
prostanoid metabolic process
prostaglandin metabolic process
unsaturated fatty acid biosynthetic process
icosanoid biosynthetic process
arachidonic acid metabolic process
cell redox homeostasis
electron transfer activity
azurophil granule lumen
fatty acid derivative biosynthetic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
heme binding
fatty acid derivative metabolic process
electron transport chain
monocarboxylic acid biosynthetic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
generation of precursor metabolites and energy
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
monocarboxylic acid metabolic process
lipid biosynthetic process
myeloid leukocyte activation
small molecule biosynthetic process