PTPLB

Gene Information

Official Symbol: HACD2
Official Name: 3-hydroxyacyl-CoA dehydratase 2
Aliases and Previous Symbols: N/A
Entrez ID: 201562
UniProt: Q6Y1H2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 1μM R03 exp100	1.7
Vinblastine 0.002μM R01 exp60	1.75
Wortmannin 0.5μM R00 exp37	1.76
Vinorelbine 0.001μM R05 exp249	1.77
Metformin 40μM R03 exp132	1.88
Nifuroxazide 5μM R03 exp102	2.07
S-DABN 8μM R03 exp112	2.16

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10633
Expression level (log2 read counts): 6.42

Expression Distribution

3-hydroxy-lignoceroyl-CoA dehydratase activity
3-hydroxy-behenoyl-CoA dehydratase activity
3-hydroxy-arachidoyl-CoA dehydratase activity
very-long-chain 3-hydroxyacyl-CoA dehydratase activity
3-hydroxyacyl-CoA dehydratase activity
very long-chain fatty acid biosynthetic process
fatty acid elongation
long-chain fatty-acyl-CoA biosynthetic process
long-chain fatty-acyl-CoA metabolic process
very long-chain fatty acid metabolic process
fatty-acyl-CoA biosynthetic process
fatty-acyl-CoA metabolic process
thioester biosynthetic process
acyl-CoA biosynthetic process
ribonucleoside bisphosphate biosynthetic process
nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
sphingolipid biosynthetic process
fatty acid derivative biosynthetic process
thioester metabolic process
acyl-CoA metabolic process
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
fatty acid biosynthetic process
membrane lipid biosynthetic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
coenzyme biosynthetic process
purine ribonucleotide biosynthetic process
sphingolipid metabolic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
fatty acid derivative metabolic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
monocarboxylic acid biosynthetic process
membrane lipid metabolic process
cofactor biosynthetic process