PTS

Entrez Summary: The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008].
UniProt Summary: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin. {ECO:0000269|PubMed:1282802}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 5ng/ml R00 exp35	-2.21
Tubacin 1.6μM R07 exp416	-2.19
Docosahexaenoic-acid 50μM R07 exp356	-2.1
Dynasore 10μM R04 exp180	-2.07
Epigallocatechin gallate 20μM R05 exp230	-1.95
TRAIL 50ng/ml R00 exp36	-1.83
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.71
THZ531 0.11μM R07 exp409	-1.71
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.7
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.78
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	2.01

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
GCH1	0.624
SPR	0.499

6-pyruvoyltetrahydropterin synthase activity
tetrahydrobiopterin biosynthetic process
tetrahydrobiopterin metabolic process
pteridine-containing compound biosynthetic process
diol biosynthetic process
diol metabolic process
pteridine-containing compound metabolic process
polyol biosynthetic process
polyol metabolic process
alcohol biosynthetic process
coenzyme biosynthetic process
organic hydroxy compound biosynthetic process
cofactor biosynthetic process
coenzyme metabolic process
cellular amino acid metabolic process
alcohol metabolic process
cofactor metabolic process
organic hydroxy compound metabolic process
drug metabolic process
small molecule biosynthetic process
protein homodimerization activity
carboxylic acid metabolic process
central nervous system development
oxoacid metabolic process
organic acid metabolic process
identical protein binding
heterocycle biosynthetic process
aromatic compound biosynthetic process
mitochondrion
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process