RAB11FIP5

Entrez Summary: N/A
UniProt Summary: Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Lenalidomide 20μM R07 exp375	1.71
Taxol 0.002μM R01 exp54	2

C2
RBD-FIP

negative regulation of adiponectin secretion
regulation of adiponectin secretion
insulin secretion involved in cellular response to glucose stimulus
cellular response to acidic pH
cellular response to pH
response to acidic pH
gamma-tubulin binding
regulation of protein localization to cell surface
insulin secretion
response to pH
transport vesicle membrane
regulation of endocrine process
peptide hormone secretion
negative regulation of hormone secretion
cellular response to glucose stimulus
cellular response to hexose stimulus
cellular response to monosaccharide stimulus
hormone secretion
cellular response to carbohydrate stimulus
hormone transport
recycling endosome membrane
secretory granule
cellular glucose homeostasis
recycling endosome
negative regulation of protein secretion
response to glucose
negative regulation of peptide secretion
response to hexose
response to monosaccharide
Rab GTPase binding
early endosome membrane
microtubule organizing center
protein secretion
establishment of protein localization to extracellular region
mitochondrial outer membrane
protein localization to extracellular region
signal release
response to carbohydrate
peptide secretion
negative regulation of protein transport