RAB4A

Entrez Summary: N/A
UniProt Summary: Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.89
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.78
Salinomycin 3.5μM R08 exp521	-1.78
Hinokiflavone 12μM R08 exp487	-1.73
Vemurafenib 6.6μM R02 exp89	-1.71
GSK-LSD1 10μM R03 exp123	1.72
BI-2536 0.001μM R01 exp41	2.21

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

postsynaptic recycling endosome
insulin-responsive compartment
anchored component of synaptic vesicle membrane
ATPase activator activity
ionotropic glutamate receptor binding
positive regulation of ATPase activity
syntaxin binding
Rab protein signal transduction
GDP binding
ATPase binding
regulation of ATPase activity
recycling endosome membrane
phosphatidylinositol biosynthetic process
vesicle
cytoplasmic vesicle membrane
early endosome membrane
phosphatidylinositol metabolic process
regulation of endocytosis
glycerophospholipid biosynthetic process
antigen processing and presentation
glycerolipid biosynthetic process
phospholipid biosynthetic process
Ras protein signal transduction
endosome
glycerophospholipid metabolic process
small GTPase mediated signal transduction
GTPase activity
phospholipid metabolic process
glycerolipid metabolic process
GTP binding
organophosphate biosynthetic process
regulation of vesicle-mediated transport
lipid biosynthetic process
intracellular membrane-bounded organelle
perinuclear region of cytoplasm
positive regulation of hydrolase activity
organophosphate metabolic process
cellular lipid metabolic process
intracellular protein transport
lipid metabolic process