RAPGEF6

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

establishment of endothelial intestinal barrier
Ras GTPase binding
microvillus assembly
phosphatidic acid binding
microvillus organization
GTP-dependent protein binding
establishment of endothelial barrier
endothelial cell development
endocytic vesicle
endothelial cell differentiation
endothelium development
guanyl-nucleotide exchange factor activity
protein localization to plasma membrane
epithelial cell development
protein localization to cell periphery
Ras protein signal transduction
apical plasma membrane
small GTPase mediated signal transduction
positive regulation of GTPase activity
plasma membrane bounded cell projection assembly
cell projection assembly
protein localization to membrane
regulation of GTPase activity
centrosome
epithelial cell differentiation
positive regulation of hydrolase activity
epithelium development
plasma membrane bounded cell projection organization
cell projection organization
regulation of hydrolase activity
positive regulation of catalytic activity
cellular protein localization
cellular macromolecule localization
cell development
intracellular signal transduction
tissue development
positive regulation of molecular function