RBBP7

Entrez Summary: N/A
UniProt Summary: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 8/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	1/18
liver	0/19
lung	0/72
lymphocyte	1/14
ovary	1/25
pancreas	0/22
peripheral nervous system	1/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/28
uterus	0/5

Expression Distribution

WD40
CAF1C H4-bd

cellular heat acclimation
heat acclimation
NuRD complex
ESC/E(Z) complex
CENP-A containing nucleosome assembly
CENP-A containing chromatin organization
chromatin remodeling at centromere
centromere complex assembly
negative regulation of G0 to G1 transition
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
regulation of G0 to G1 transition
histone exchange
cellular response to heat
ATP-dependent chromatin remodeling
negative regulation of gene expression, epigenetic
response to heat
nucleosome assembly
chromatin assembly
chromatin assembly or disassembly
nucleosome organization
chromatin remodeling
response to temperature stimulus
DNA packaging
regulation of signal transduction by p53 class mediator
negative regulation of cell growth
protein-DNA complex assembly
DNA replication
regulation of gene expression, epigenetic
protein-DNA complex subunit organization
negative regulation of growth
DNA conformation change
negative regulation of cell cycle process
response to steroid hormone
post-translational protein modification
regulation of cell growth
negative regulation of cell cycle
regulation of growth
chromatin organization
regulation of cell cycle process