RBFOX1
Gene Information
- Official Symbol: RBFOX1
- Official Name: RNA binding fox-1 homolog 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 54715
- UniProt: Q9NWB1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
- UniProt Summary: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. {ECO:0000269|PubMed:16537540}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11914
- Expression level (log2 read counts): -3.42
RBFOX1 Expression in NALM6 Cells: -3.42
