RBKS

Entrez Summary: N/A
UniProt Summary: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. {ECO:0000255|HAMAP-Rule:MF_03215, ECO:0000269|PubMed:17585908}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nutlin-3A 1.6μM R06 exp294	-2.19
Nifuroxazide 5μM R03 exp102	-2.09
SB743921 0.001μM R05 exp244	-2.09
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.72
CHIR-124 0.04μM R06 exp272	1.7

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PfkB
Phos pyr kin

ribokinase activity
D-ribose catabolic process
D-ribose metabolic process
pentose catabolic process
pentose-phosphate shunt
NADPH regeneration
pentose metabolic process
glucose 6-phosphate metabolic process
carbohydrate phosphorylation
NADP metabolic process
monosaccharide catabolic process
carbohydrate catabolic process
cellular carbohydrate metabolic process
monosaccharide metabolic process
generation of precursor metabolites and energy
small molecule catabolic process
carbohydrate metabolic process
organophosphate metabolic process
oxidation-reduction process
carbohydrate derivative metabolic process
phosphorylation
ATP binding
small molecule metabolic process
organic substance catabolic process