RBM22

Entrez Summary: N/A
UniProt Summary: Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:22246180}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SNS-032 25μM R07 exp401	-2.01
Deferoxamine 11μM R07 exp350	-1.75
Cabazitaxel 0.001μM R05 exp223	1.7
Chloramphenicol 2μM R00 exp12	1.79
Lead acetate 2000μM R08 exp498 no dilution day6	1.86
TRAIL 50ng/ml R00 exp36	2.04
Cadmium 60μM R08 exp462	2.12
D-Fructose 10000μM R06 exp279	2.22
Bortezomib 0.005μM R00 exp6	2.64

Global Fraction of Cell Lines Where Essential: 738/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

U6 snRNA binding
U2-type catalytic step 1 spliceosome
Prp19 complex
pre-mRNA binding
positive regulation of protein export from nucleus
U2-type catalytic step 2 spliceosome
mRNA cis splicing, via spliceosome
positive regulation of RNA splicing
positive regulation of protein import into nucleus
regulation of protein export from nucleus
positive regulation of protein import
regulation of protein import into nucleus
regulation of protein import
calcium-dependent protein binding
positive regulation of nucleocytoplasmic transport
positive regulation of protein localization to nucleus
catalytic step 2 spliceosome
regulation of nucleocytoplasmic transport
regulation of protein localization to nucleus
regulation of RNA splicing
positive regulation of intracellular protein transport
positive regulation of intracellular transport
regulation of intracellular protein transport
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
positive regulation of cellular protein localization
regulation of intracellular transport
RNA splicing
cellular response to drug
positive regulation of protein transport
positive regulation of establishment of protein localization
mRNA processing
regulation of cellular protein localization
mRNA metabolic process
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
RNA processing
regulation of cellular localization